This is a list of the Canadian RPM magazine number one singles of 1980.
| Volume:Issue | Issue Date(s) | Weeks on Top | Song | Artist |
| 32:15 | 5 January | 1 | "Babe" | Styx |
| 32:16-17 | 12 January - 19 January | 2 | "Escape" | Rupert Holmes |
| 32:18-19 | 26 January - 2 February | 2 | "Rapper's Delight" | Sugarhill Gang |
| 32:20 | 9 February | 1 | "Coward of the County" | Kenny Rogers |
| 32:21 | 16 February | 1 | "Please Don't Go" | KC and the Sunshine Band |
| 32:22-23 | 23 February - 1 March | 2 | "Crazy Little Thing Called Love" | Queen |
| 32:24-25 | 8 March - 15 March | 2 | "Coward of the County" (re-entry) | Kenny Rogers |
| 32:26-33:5 | 22 March - 26 April | 6 | "Another Brick in the Wall (Part II)" | Pink Floyd |
| 33:6-8 | 3 May - 17 May | 3 | "Call Me" | Blondie |
| 33:9 | 24 May | 1 | "Rock Lobster" | The B-52's |
| 33:10-12 | 31 May - 14 June | 3 | "Call Me" (re-entry) | Blondie |
| 33:13-14 | 21 June - 28 June | 2 | "Cars" | Gary Numan |
| 33:15 | 5 July | 1 | "Coming Up" | Paul McCartney |
| 33:16 | 12 July | 1 | "Funkytown" | Lipps Inc |
| 33:17 | 19 July | 1 | "Little Jeannie" | Elton John |
| 33:18-20 | 26 July - 9 August | 3 | "It's Still Rock and Roll to Me" | Billy Joel |
| 33:21 | 16 August | 1 | "Misunderstanding" | Genesis |
| 33:22-25 | 23 August - 20 September | 5 | "Emotional Rescue" | The Rolling Stones |
| 33:26 | 27 September - 4 October | 2 | "Magic" | Olivia Newton-John |
| 34:1 | 11 October - 18 October | 2 | "Sailing" | Christopher Cross |
| 34:2-3 | 25 October - 15 November | 4 | "Another One Bites the Dust" | Queen |
| 34:4 | 22 November - 29 November | 2 | "Woman in Love" | Barbra Streisand |
| 34:5 | 6 December - 13 December | 2 | "Dreamer" | Supertramp |
| 34:6 | 20 December - 27 December | 2 | "(Just Like) Starting Over" | John Lennon |
During the August-September time frame, RPM apparently adopted a fortnightly publishing schedule, based on issue numbers. Therefore each chart in the latter portion of 1980 covered two weeks.
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